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Functional assessment of type III secreted Sop effector proteins from Salmonella in eukaryotic cells

Reference	D18830
Principal Investigator / Supervisor	Dr Edouard Galyov
Co-Investigators / Co-Supervisors
Institution	The Pirbright Institute
Department	Div of Molecular Biology Pirbright
Funding type	Research
Value (£)	180,576
Status	Completed
Type	Research Grant
Start date	01/10/2003
End date	30/09/2006
Duration	36 months

Abstract

Activities of Salmonella outer proteins (Sops) that are involved in the induction of enteropathogenic responses in the infected host will be investigated using a combination of molecular and cell biology approaches. Each Sop protein (SopA, SopB, and SopD) will be expressed in eukaryotic cells and cellular responses elicited by such expression will be assessed. Finally, phenotypes discovered in these in vitro experiments will be verified using experimental infections of eukaryotic cells with different relevant Salmonella mutant strains.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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