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Gut-brain signalling in man: modulation of the cholecystokinin-vagus nerve pathway

Reference	D18828
Principal Investigator / Supervisor	Professor Graham Dockray
Co-Investigators / Co-Supervisors	Dr R Dimaline, Professor David Thompson, Professor Andrea Varro
Institution	University of Liverpool
Department	Physiology
Funding type	Research
Value (£)	386,292
Status	Completed
Type	Research Grant
Start date	01/09/2003
End date	31/08/2006
Duration	36 months

Abstract

The gut hormone cholecystokinin (CCK) is released by fatty acids with chain length greater than C12 and in turn inhibits gastric emptying, at least in part by acting at CCK-A receptors on vagal afferent nerve fibres. Recent work supports the hypothesis that other peptides (ghrelin, orexin and leptin) from the gut modulate these responses. The mechanisms are relevant to the regulation of food intake but remain poorly understood. We propose to define the expression and distribution of ghrelin and CCK receptors in human vagal afferent neurons, and to examine functional interactions between these and other modulators of gut-brain signalling in man.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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