Award details

Apolipoprotein E genotype and the mechanism of low density lipoprotein (LDL) cholesterol response to fish oil fatty acids

Reference	D18350
Principal Investigator / Supervisor	Prof. Anne-Marie Minihane
Co-Investigators / Co-Supervisors	Professor Christine Williams
Institution	University of Reading
Department	Food and Nutritional Sciences
Funding type	Research
Value (£)	162,688
Status	Completed
Type	Research Grant
Start date	02/06/2003
End date	01/06/2006
Duration	36 months

Abstract

In our previous study in which we investigated the effects of fish oil fatty acids on the expression of lipoprotein lipase in human adipose tissue we made the unexpected and novel observation that fish-oil induced increases in plasma LDL-C were seen only in subjects with an apoE4 genotype (approx 20 per cent population). The present study will employ 2H-leucine labelled apoB-100 and 2H-glycerol labelled TG turnover studies to examine the underlying mechanisms involved. The hypothesis is that increased LDL-C in apoE4 subjects is the result of a greater impact of the docosahexaenoic acid fraction of fish oils on hepatic and extra hepatic metabolism resulting in: (i) increased fractional production rate (FPR) of LDL from VLDL and (ii) decreased fractional catabolic rate (FCR) of LDL particles by the hepatic LDL receptor. (Joint with grant 18358).

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

D18358 Apolipoprotein E genotype and the mechanisms of low density lipoprotein (LDL) cholesterol response to fish oil fatty acids

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