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Linkage disequilibrium analysis in natural plant populations for high-resolution gene mapping

Reference	D18078
Principal Investigator / Supervisor	Professor Leif Skot
Co-Investigators / Co-Supervisors	Dr Nigel Sackville-Hamilton, Dr Danny Thorogood
Institution	Inst of Grassland and Environmental Res
Department	Soil Environmental and Ecological Sci
Funding type	Research
Value (£)	173,060
Status	Completed
Type	Research Grant
Start date	01/10/2003
End date	31/12/2006
Duration	39 months

Abstract

Linkage disequilibrium (LD) is the non-random distribution of alleles at linked loci. LD can be exploited in very high-resolution gene mapping, a prerequisite for positional gene cloning and improved breeding strategies. We propose to determine the extent and distribution of LD across a plant genome by amplified fragment length polymorphism and short sequence repeat as markers in populations of Lolium perenne, which has unique advantages for the exploitation of LD. We shall confirm the value of LD by fine-mapping three traits of increasing complexity: the two-locus di-allelic seedling root fluorescence phenotype; the two-locus multi-allelic self- incompatibility; and finally, date of flowering, a highly complex trait.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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