Award details

The impact of diet in pregnancy on the mechanisms linking cardiovascular control and growth in the fetus

Reference	D17858
Principal Investigator / Supervisor	Dr Lucy Green
Co-Investigators / Co-Supervisors	Professor Mark Hanson
Institution	University of Southampton
Department	Development Origin of Health and Disease
Funding type	Research
Value (£)	306,436
Status	Completed
Type	Research Grant
Start date	17/09/2003
End date	16/09/2006
Duration	36 months

Abstract

Small or disproportionate size at birth is associated with increased risk of adult cardiovascular disease. Impaired maternal diet or body proportions are implicated in such fetal programming of adult disease. Fetal cardiovascular and growth responses to hypoxia are well characterised, but there is no data on the role of nutrition in linking fetal tissue growth and local blood flow. In sheep, using our expertise in fetal physiology and molecular biology, we will investigate whether fetal programming involves perturbation of the renin-angiotensin system, which plays dual roles in growth and blood flow regulation. This work is fundamental to developing clinical diagnosis of individuals at risk of cardiovascular disease in later life.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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