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Influence of fatty acids on membrane lipid rafts and enterocyte function

Reference	D17799
Principal Investigator / Supervisor	Dr Philip Padfield
Co-Investigators / Co-Supervisors	Professor John McLaughlin, Dr Catherine Anne O'Neill
Institution	The University of Manchester
Department	Medical and Human Sciences
Funding type	Research
Value (£)	154,852
Status	Completed
Type	Research Grant
Start date	01/06/2003
End date	01/06/2006
Duration	36 months

Abstract

Dietary omega-3 polyunsaturated fatty acids (PUFAs) have a significant impact on a range of enterocyte functions. Exactly how omega-3 PUFAs produce these responses is unclear. One possibility is that PUFAs adversely influence the organisation, and therefore function, of enterocyte membrane lipid rafts. Lipid rafts are microdomains within the plasma membrane that are critical elements in a number of key cellular processes including intracellular signalling and vesicular transport. This application will initially establish how omega-3 PUFAs alter the composition and organisation of enterocyte lipid rafts. Subsequent studies will determine whether omega-3 PUFAs influence a subset of raft functions, including transcytosis and tight junction assembly, associated with gut barrier function.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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