BBSRC Portfolio Analyser
Award details
Role of lymphostatin in the colonisation of cattle by enterohaemorragic Escherichia coli
Reference
D17455
Principal Investigator / Supervisor
Professor Mark Stevens
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Microbiology Compton
Funding type
Research
Value (£)
283,708
Status
Completed
Type
Research Grant
Start date
21/10/2002
End date
21/10/2005
Duration
36 months
Abstract
Enterohaemorrhagic E. coli (EHEC) are emerging zoonotic pathogens and cattle are a major reservoir of human infections. We have identified a gene (lifA) that influences intestinal colonisation of calves by non-0157 EHEC. LifA (lymphostatin) acts both as an inhibitor of lymphocyte function and as an adhesin in vitro. We aim to determine how lymphostatin influences intestinal colonisation through integration of genetic techniques and the in vitro and in vivo analysis of EHEC-interactions with bovine epithelial and lymphoid cells. The roles of an E. coli O157:H7 lifA homologue (17095) and truncated lifA gene will also be investigated. We will dissect the functional domains of lymphostatin to gain insights into its mechanism of action.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search