Award details

The role of orexigenic and anorexigenic pathways in nutritional regulation of the reproductive neuroendocrine axis

Reference	D17281
Principal Investigator / Supervisor	Dr David Miller
Co-Investigators / Co-Supervisors
Institution	University of Aberdeen
Department	Agriculture and Forestry
Funding type	Research
Value (£)	201,352
Status	Completed
Type	Research Grant
Start date	23/12/2002
End date	22/11/2004
Duration	23 months

Abstract

Obesity and infertility are symptoms of inappropriate body weight. Since both axes are regulated by nutritional feedback within the same brain region (hypothalamus), they share common mechanisms. Better knowledge of these is needed to develop correct therapies for sustained weight loss and improved reproductive health. Nutrition influences reproduction via gonadotrophin releasing-hormone (GnRH) output. Our animal model shows that the hypothalamus has a nutritional memory, dissociating dynamic and static feedback, with differential effects on GnRH. We hypothesise that peripheral feedback from leptin, insulin and ghrelin modulates GnRH through hypothalamic pathways shared with energy balance regulation; these will be tested in our animal model using in vivo intrahypothalamic sampling:infusion and in vitro gene expression analysis.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

D17281/2 The role of orexigenic and anorexigenic pathways in nutritional regulation of the reproductive neuroendocrine axis

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