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Neurohormonal regulation of energetically-coupled transporters involved in nutrient absorption and pHi homeostasis
Reference
D17277
Principal Investigator / Supervisor
Professor David Thwaites
Co-Investigators /
Co-Supervisors
Professor Nicholas Simmons
Institution
Newcastle University
Department
School of Cell and Molecular Biosciences
Funding type
Research
Value (£)
383,152
Status
Completed
Type
Research Grant
Start date
01/04/2002
End date
31/12/2005
Duration
45 months
Abstract
This project seeks to define how control of intestinal enterocyte function optimises nutrient absorption in the form of small peptides. Coordinate regulation (at both cellular and molecular levels) of the transport protein hPepT1 and the Na+:H+ exchanger NHE3 will be investigated using the human intestinal epithelial cell line Caco-2 and a mouse knockout model. The cell signalling pathways activated by hormonal, neural and paracrine factors will be identified using a range of selective pharmacological tools. Experiments using intestinal tissues from NHE3-deficient mice will investigate the absolute dependence of hPepT1 activity on NHE3 coupling, and the adaptive alterations in gut function following extreme perturbation (NHE3 ablation).
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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