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Vaccination against prion disease
Reference
D17183
Principal Investigator / Supervisor
Dr Raymond Bujdoso
Co-Investigators /
Co-Supervisors
Dr Alana Thackray
Institution
University of Cambridge
Department
Veterinary Medicine
Funding type
Research
Value (£)
200,496
Status
Completed
Type
Research Grant
Start date
01/02/2003
End date
31/07/2005
Duration
30 months
Abstract
Vaccination against CNS neurodegenerative conformational disease has become a realistic possibility. There are now several clear lines of evidence which support the view that anti- PrP antibodies may interfere with the conversion of PrPc to PrPSc and retard the progression of prion disease. Here we will test the hypothesis that prion disease induced by peripheral inoculation can be modulated by vaccination against PrP. Specifically, we will investigate whether the extent and progression of prion disease can be suppressed by one or more of the following: (i) passive immunisation with anti-PrP monoclonal antibodies; (ii) plasmid DNA vaccination with constructs that express PrPc, (iii) adoptive transfer of PrPc -loaded dendritic cells.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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