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Molecular mechanisms by which n-3 fatty acids reduce inflammatory responses and cartilage degradation in arthritis
Reference
D16961
Principal Investigator / Supervisor
Professor John Harwood
Co-Investigators /
Co-Supervisors
Professor Bruce Caterson
,
Professor Simon Jones
Institution
Cardiff University
Department
School of Biosciences
Funding type
Research
Value (£)
290,968
Status
Completed
Type
Research Grant
Start date
01/07/2002
End date
30/06/2005
Duration
36 months
Abstract
Dietary factors influence immune reactions associated with arthritis progression but the underlying molecular basis is not understood. We will extend our previous studies on n-3 fatty acids by using chondrocyte cultures and samples from patients undergoing surgery to probe in detail how fatty acids are able to modulate immune responses. The potency of different n-3 fatty acids (and interactions with n-6 fatty acids) in altering mRNA, protein and activity for factors relevant to arthritis (e.g. aggrecanases, COXs, LOXs, TNF-alpha, chemokines) will be studied. Signalling pathways involved will be explored (arrays, inhibitors) and quantified by control analysis. These studies are important for basic understanding as well as to develop new treatments.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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