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An investigation into host genetic resistance to campylobacter colonisation in poultry
Reference
D16959
Principal Investigator / Supervisor
Professor Paul Barrow
Co-Investigators /
Co-Supervisors
Institution
The Pirbright Institute
Department
Div of Molecular Biology Pirbright
Funding type
Research
Value (£)
254,768
Status
Completed
Type
Research Grant
Start date
27/05/2002
End date
26/05/2005
Duration
36 months
Abstract
Campylobacter is an intestinal commensal of poultry flocks and a major food-borne pathogen in man. Differences in the level of cloacal colonisation by C. jejuni have been found in the IAH inbred lines of chickens after challenge on the day-of-hatch, with line 6(1) being relatively resistant and line N relatively sensitive. These differences will be characterised further by quantitative measurement of Campylobacter in caeca and other tissues. Genetic crosses segregating the differences will be established and analysed with microsatellite markers covering the chicken genome. High resolution comparative maps will be constructed across genomic regions identified as conferring resistance and used, together with database mining, to select positional candidates. These will be sequenced in resistant and susceptible chicken lines.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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