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Mechanisms of gene dysregulation in the human colon by the dietary compound butyrate
Reference
D16937
Principal Investigator / Supervisor
Professor Caroline Dive
Co-Investigators /
Co-Supervisors
Professor Bernard Corfe
Institution
The University of Manchester
Department
Life Sciences
Funding type
Research
Value (£)
254,660
Status
Completed
Type
Research Grant
Start date
01/04/2002
End date
01/12/2005
Duration
44 months
Abstract
Colorectal cancer (CRC) is a major killer in the Western world. Data suggests that nutritional factors may reduce risk of CRC. Amongst these factors is butyrate, which has been shown to protect against tumourigenesis in vivo and to drive apoptosis in vitro. A likely mechanism of butyrate mediated apoptosis is the transcriptional up-regulation of pro-apoptotic proteins Bak and Bax. We will determine the role of Bak and Bax at apoptosis after butyrate treatment. We will investigate how butyrate-mediated changes in the chromatin structure of the Bak/Bax promoters change expression levels of these genes. Thus we will examine how a nutrient factor may alter gene expression, leading to the suppression of oncogenesis.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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