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Toll-like receptors modulate the host immune response to infection with Salmonella typhimurium

Reference	D16845
Principal Investigator / Supervisor	Professor Duncan Maskell
Co-Investigators / Co-Supervisors
Institution	University of Cambridge
Department	Veterinary Medicine
Funding type	Research
Value (£)	271,188
Status	Completed
Type	Research Grant
Start date	01/03/2002
End date	31/03/2005
Duration	37 months

Abstract

Salmonella species cause a wide range of disease syndromes in many hosts. In mice S. typhimurium causes a severe invasive disease, similar to those seen in other host species. The lipid A domain of S. typhimurium lipopolysaccharide (LPS) is critical in causing death in mouse typhoid infections, probably via production of high levels of cytokine mediators from macrophages. Macrophage responses are modulated by LPS, live bacteria and bacterial products (e.g. lipoproteins, DNA) which are recognised, at least in part, through Toll-like receptors (TLRs), a group of key regulatory proteins in mammals. Using TLR knock-out mice this study will investigate the hypothesis that both the protective innate response and the lethality seen in different Salmonella infections in mice, are both dependent on interactions between lipid A and/or other bacterial products and TLRs.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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