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Metabolic and pathogenic mechanisms of loss in supportive capacity of bovine hooves at calving leading to lameness

Reference	D16045
Principal Investigator / Supervisor	Professor John Tarlton
Co-Investigators / Co-Supervisors	Mr Nicholas Avery, Professor Anthony John Webster
Institution	University of Bristol
Department	Clinical Veterinary Science
Funding type	Research
Value (£)	282,148
Status	Completed
Type	Research Grant
Start date	01/01/2002
End date	31/05/2005
Duration	41 months

Abstract

Lameness in dairy cattle is a major and increasing welfare problem, and with loss in productivity, and the labour and cost of treatment, represents a major economic burden for the diary farmer. It has defied improved husbandry practice because its underlying pathogenic mechanisms are unknown, and there are few available therapeutic targets. Our preliminary work has indicated that reduced supportive capacity of the hoof connective tissues are a primary cause in lameness associated with calving. We plan to investigate the biochemical mechanisms and hormonal induction of these changes in a well defined and controlled study, looking at the effects of calving and diet, and aim to identify new targets for improved husbandry and therapy.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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