Award details

Function of the Flp operons of Lactococcus lactis spp cremoris MG1363

Reference	D16001
Principal Investigator / Supervisor	Professor J Green
Co-Investigators / Co-Supervisors	Professor Peter Artymiuk, Professor Michael Gasson, Dr Claire Shearman
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	331,760
Status	Completed
Type	Research Grant
Start date	01/06/2002
End date	31/08/2006
Duration	51 months

Abstract

We recently identified two FNR-like proteins (Flp) that are involved in regulating the response to oxidative stress in the commercially important bacterium L. lactis. Thus there is an opportunity to use these global regulators for strain and process improvement. Because of the location of the flp genes (distal genes of paralogous three gene operons encoding predicted metallochaperones and Dps-like proteins) novel mechanisms to counter oxidative stress are suggested. Using a two- centred multidisciplinary approach that includes molecular genetics, proteomics, biochemistry and structural biology we aim to provide a detailed characterisation of the properties and functions of the encoded proteins. These studies should provide new and potentially exploitable insights into the oxidative stress responses of the lactic acid bacteria. (Joint with grant 218/D16002).

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

D16002 Functions of the Flp operons of Lactococcus lactis spp cremoris MG1363

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