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Transfer of newly identified antibiotic resistance genes between bacteria in different gut and non gut environments
Reference
D15925
Principal Investigator / Supervisor
Professor Peter Mullany
Co-Investigators /
Co-Supervisors
Institution
University College London
Department
Eastman Dental Institute
Funding type
Research
Value (£)
164,244
Status
Completed
Type
Research Grant
Start date
18/02/2002
End date
17/08/2005
Duration
42 months
Abstract
Gut microbial communities are potentially a key site for gene flow between environmental bacteria, commensal and pathogenic gut bacteria. The recent identification of novel, highly homologous, tetracycline resistance genes in several of the predominant genera of gut bacteria provides an important opportunity to analyse the mechanisms and extent of gene flow. In addition to describing new classes of transposable elements in Gram positive species this research will use flanking sequences and internal abR gene sequences to give information in the recent history if TcR gene exchange amongst these bacterial groups, and thus on the role of the commensal flora in harbouring resistance transferable to pathogens.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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