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Award details
An investigation into multiple glycosylation in Campylobacter jejuni
Reference
D15819
Principal Investigator / Supervisor
Professor Brendan Wren
Co-Investigators /
Co-Supervisors
Institution
London Sch of Hygiene and Trop Medicine
Department
Infectious and Tropical Diseases
Funding type
Research
Value (£)
204,012
Status
Completed
Type
Research Grant
Start date
24/07/2002
End date
24/07/2005
Duration
36 months
Abstract
In bacterial cells, glycosylation is an unusual and generally highly significant modification of proteins. This project builds on convincing data in the award holder's laboratory that has identified ten new C. jejuni glycoproteins including Peb3. Given the surface location and antigenic nature of glycoproteins we propose that they play a role in the interaction of C. jejuni with host cells and host immune systems. This project will identify mutants and characterise the putative glycoproteins and investigate their role, particularly in relation to binding to different cells. As Peb3 is a known adhesin, the structure of this glycoprotein will be determined. The study of these novel glycoproteins will provide much new data on this poorly studied pathogen that should facilitate improved diagnostic and intervention strategies to reduce the burden of C. jejuni disease.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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