Award details

Dietary and genetic factors modulating DNA repair capacity

Reference	D15721
Principal Investigator / Supervisor	Professor John Hesketh
Co-Investigators / Co-Supervisors	Professor Ann Daly, Professor John Mathers, Dr E Williams
Institution	Newcastle University
Department	Agriculture Food and Rural Development
Funding type	Research
Value (£)	317,680
Status	Completed
Type	Research Grant
Start date	20/05/2002
End date	19/05/2005
Duration	36 months

Abstract

This proposal will test the linked hypotheses that a) there is phenotypic inter-individual variation in the ability to repair DNA damage, b) that this variation is a consequence of genetic polymorphisms in the enzymes responsible for DNA repair and c) that individuals with specific genotypes have heightened sensitivity to the modifying effects of dietary factors on DNA repair. Failure to repair DNA predisposes to colon cancer. We will measure DNA repair capacity in volunteers before and after dietary intervention, and identify genetic polymorphisms in key base excision repair genes using DNA fragment analysis. Lymphoblastoid cell lines will be derived from volunteers and used to investigate modulation of DNA repair by dietary factors.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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