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Characterisation of the effect of Salmonella-induced intestinal inflammation on pathogenesis
Reference
D15635
Principal Investigator / Supervisor
Dr Timothy Wallis
Co-Investigators /
Co-Supervisors
Dr Jennifer Bispham
,
Dr Edouard Galyov
Institution
The Pirbright Institute
Department
Div of Microbiology Compton
Funding type
Research
Value (£)
205,976
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
31/03/2005
Duration
42 months
Abstract
This Group has identified several virulence factors that are involved in the induction of Salmonella-induced inflammation and has shown that this is both host- and serotype-specific. Several unconnected studies have demonstrated that Salmonella modulation of pro- inflammatory cytokines can be both host- and serotype- dependent. In this proposal we aim to study Salmonella- induced intestinal inflammatory responses in the context of pathogenesis and host-specificity in a coordinated study using strains of defined virulence in pigs. Determining how Salmonella modulate intestinal inflammatory responses in the context of host specificity is potentially essential for understanding the pathogenesis of this complex zoonotic pathogen.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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