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The functional role of pyruvate dehydrogenase kinase in human skeletal muscle in various nutritional states
Reference
D15633
Principal Investigator / Supervisor
Professor Kostas Tsintzas
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
Sch of Biomedical Sciences
Funding type
Research
Value (£)
187,696
Status
Completed
Type
Research Grant
Start date
01/06/2002
End date
30/11/2005
Duration
42 months
Abstract
There is evidence, particularly from animal studies, for a role for muscle pyruvate dehydrogenase kinase (PDK) in the development of insulin resistance in nutritional states characterised by elevated lipid metabolism. Two isoforms of PDK (PDK2 and PDK4) have been identified in human skeletal muscle. This is the most important tissue for insulin-mediated glucose uptake, and as such it is also the primary site of insulin resistance. The aim of this project is to examine the effect of various nutritional states, that are known to alter fat availability and insulin sensitivity, on the expression of PDK2 and PDK4 in biopsy muscle samples from human volunteers, and relate those measurements to changes in substrate utilisation and insulin action.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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