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Interactions of cytokine genotype and n-3 PUFA intake on the inflammatory effects of monocyte/ macrophages on endothelium

Reference	D15532
Principal Investigator / Supervisor	Professor Robert Grimble
Co-Investigators / Co-Supervisors	Professor Philip Calder, Professor Gerard Nash
Institution	University of Southampton
Department	Development Origin of Health and Disease
Funding type	Research
Value (£)	458,352
Status	Completed
Type	Research Grant
Start date	01/02/2002
End date	30/04/2005
Duration	39 months

Abstract

Formation of atheroma is promoted by monocyte/macrophages in the artery wall, which cause local inflammation and recruitment of leukocytes. Major modulators of this cycle may be an individual's intake of specific fatty acids and cytokine genotype. Monocyte/macrophages will be cultured alone and with endothelial cells (EC), and optimal conditions and endpoints defined, for measuring cytokine secretion and activation of EC to capture flowing leukocytes. Donors (healthy and with artherosclerosis, with characterised cytokine genotype) will be studied before and after supplementation with n-3 polyunsaturated fatty acids. We aim to show how diet and genotype influence the ability of monocyte/macrophages to stimulate EC to capture leukocytes and promote atherosclerosis at an individual level.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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