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Molecular mechanisms of action of isoflavones on glutathione induction in human cultured cells and in vivo
Reference
D15524
Principal Investigator / Supervisor
Professor Jeremy Spencer
Co-Investigators /
Co-Supervisors
Prof. Anne-Marie Minihane
Institution
University of Reading
Department
Food and Nutritional Sciences
Funding type
Research
Value (£)
151,448
Status
Completed
Type
Research Grant
Start date
01/07/2002
End date
30/06/2005
Duration
36 months
Abstract
Prelimary data indicate that isoflavones increase cellular GSH in human endothelial cells. The project will determine the molecular targets and underlying signal transduction pathways of isoflavones in cultured cells. We will study the effect of isoflavones on transcription factor activation (AP-1, NF-kB, Nrf-1, Nrf-2) and gamma glutamyl cysteinyl synthetase gene and protein expression in human endothelial cells, fibroblasts and hepatocytes.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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