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Mechanisms and consequences of dietary-induced alterations in chylomicron particle size and composition

Reference	D15215
Principal Investigator / Supervisor	Professor Christine Williams
Co-Investigators / Co-Supervisors	Dr Kim Jackson, Professor Gerald Rimbach, Professor Parveen Yaqoob
Institution	University of Reading
Department	Food and Nutritional Sciences
Funding type	Research
Value (£)	287,376
Status	Completed
Type	Research Grant
Start date	01/06/2001
End date	01/06/2004
Duration	36 months

Abstract

Our previous studies suggest dietary fatty acid manipulation results in alterations in chylomicron particle size and composition in humans. We will test the hypotheses that these changes are the result of fatty acid induced alterations in enterocyte gene expression, and that chylomicron particle size and composition is: (a) a determinant of its rate of hydrolysis by LPL, and (b) influences the gene expression of hepatic HMGCoA reductase and the LDL receptor. We will use antibody-coated magnetic beads to isolate CM particles from VLDL in plasma of volunteers who have undergone meal and longer term dietary studies. This will allow direct measurement of CM particle size and in vitro studies of susceptibility to LPL hydrolysis.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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