Award details

Control of somatic cell differentiation and oocyte development during early folliculogenesis: a new hypothesis

Reference	D15115
Principal Investigator / Supervisor	Dr David Armstrong
Co-Investigators / Co-Supervisors	Professor Bruce Campbell, Professor Evelyn Telfer
Institution	The Roslin Institute
Department	Dept of Reproductive & Env Physiology
Funding type	Research
Value (£)	118,880
Status	Completed
Type	Research Grant
Start date	01/08/2001
End date	01/08/2004
Duration	36 months

Abstract

Early follicle growth and oocyte development is poorly understood and markers of somatic cell differentiation and oocyte development are required to advance knowledge in this area. Observations in our laboratory suggest that insulin like growth factor binding protein-2 (IGFBP-2) may be such a marker of early follicle growth through its ability to regulate intrafollicular IGF bioavailability. We propose to utilise novel in vivo and in vitro model systems to test the hypothesis that temporal changes in the expression and proteolysis of IGFBP-2 are key determinants of preantral follicle growth. These observations will be correlated to the developmental potential of the oocyte and should contribute to the development of technologies for increasing the availability of oocytes from cattle of high genetic merit for subsequent use in IVF and embryo transfer protocols. (Joint with grant 42/D15313).

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

D15313 Control of somatic cell differentiation and oocyte development during early folliculogenesis: a new hypothesis

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