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Mechanisms underlying the atherogenicity of triglyceride-rich lipoproteins and their remnants
Reference
D15032
Principal Investigator / Supervisor
Professor Parveen Yaqoob
Co-Investigators /
Co-Supervisors
Professor Christine Williams
Institution
University of Reading
Department
Food and Nutritional Sciences
Funding type
Research
Value (£)
277,556
Status
Completed
Type
Research Grant
Start date
01/09/2001
End date
01/09/2004
Duration
36 months
Abstract
Postprandial triglyceride levels have been demonstrated to be an independent predictor of coronary heart disease, but the mechanisms underlying the atherogenicity of triglyceride-rich lipoproteins are not well understood. There is evidence that both chylomicrons and very low density lipoprotein can induce foam cell formation by monocyte-derived macrophages. This project aims to examine the mechanisms by which selected subfractions of triglyceride-rich lipoproteins of known size and density are taken up by monocyte- derived macrophages in both normal healthy individuals and subjects with an atherogenic lipoprotein phenotype.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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