Award details

Identification of immune subsets that contribute to IFNgamma-dependent protection against S. typhimurium in vivo

Reference	D14755
Principal Investigator / Supervisor	Dr Adrian Smith
Co-Investigators / Co-Supervisors	Dr Pietro Mastroeni, Professor Bernardo Villarreal-Ramos
Institution	The Pirbright Institute
Department	Compton Laboratory
Funding type	Research
Value (£)	215,256
Status	Completed
Type	Research Grant
Start date	01/11/2001
End date	01/11/2004
Duration	36 months

Abstract

Salmonellosis is a food-borne zoonosis with important medical and veterinary implications. Continued reduction of antibiotic usage in livestock is a priority and the development of more efficacious vaccines is an appropriate and sustainable method of control. Rational vaccine design requires a thorough understanding of the immune cell types and immune mechanisms that operate against Salmonella infection in vivo. Interferon gamma is important in the anti-salmonella response but the cellular source(s) of effective IFNgamma remain unknown. This proposal will identify the relative contribution of different cell types to the IFNgamma- dependent effector response that operate at different phases of primary and challenge infections.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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