Award details

Influence of intestinal absorption and metabolism of dietary flavonoids on their activities as antioxidants

Reference	D14751
Principal Investigator / Supervisor	Dr C Rice-Evans
Co-Investigators / Co-Supervisors	Dr Edward Debnam, Professor Jeremy Spencer, Professor Surjit Srai, Dr Robert Williams
Institution	King's College London
Department	Division of Biochemistry & Molecular Bio
Funding type	Research
Value (£)	120,120
Status	Completed
Type	Research Grant
Start date	01/03/2001
End date	01/03/2003
Duration	24 months

Abstract

The powerful antioxidant properties of dietary flavonoids in vitro depend on the arrangement and availability of the phenolic hydroxyl groups. The purpose of this submission is to determine how the antioxidant properties of flavonoids are compromised by the conjugation and metabolism that occur on transport across the small intestine, and the structural dependence of these effects. Caco-2 cells will be used as a model of human small intestine and HPLC and LCMS applied for structural characterisation. Antioxidant activities of the resulting conjugates and metabolites will be screened for their abilities to function as hydrogen donors, to scavenge reactive nitrogen species and to protect neuronal cells against oxidative stress.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search