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The influence of neuromuscular stimulation in the avian embryo on muscle development
Reference
D14644
Principal Investigator / Supervisor
Professor Neil Stickland
Co-Investigators /
Co-Supervisors
Institution
Royal Veterinary College
Department
Veterinary Basic Sciences - London
Funding type
Research
Value (£)
237,836
Status
Completed
Type
Research Grant
Start date
01/04/2001
End date
01/07/2005
Duration
51 months
Abstract
Our pilot studies have indicated that increased neuromuscular stimulation in developing chicken embryos has a profound influence on muscle fibre number determination. The aim of this project is to test the hypothesis that this is due to increased or prolonged myoblast proliferation due to delayed differentiation and/or decreased apoptosis. The mechanisms underlying these responses will be investigated by analysing the expression of the IGF system, myogenic regulatory factors, cyclin inhibitors and neurotrophins. A range of structural and molecular techniques will be used to analyse muscles from chick embryos and hatchlings given neuromuscular stimulants and blockers in early development. In a wider context this project will help us to understand the early determination of muscle fibre number, a parameter of known importance in determining the meat potential of an animal.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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