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Award details
The role of anaerobic respiration in survival colonisation and pathogenicity of Campylobacter jejuni
Reference
D14520
Principal Investigator / Supervisor
Professor Charles Penn
Co-Investigators /
Co-Supervisors
Professor Jeffrey Cole
Institution
University of Birmingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
181,216
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
31/12/2004
Duration
39 months
Abstract
This project will assess the importance of genetic determinants of anaerobic growth in the pathogenicity of C. jejuni. We will investigate the range of conditions that support anaerobic growth; characterise the phenotype of the resulting bacteria; identify proteins expressed specifically during anaerobic or oxygen- limited growth; compare transcripts of aerobically and anaerobically grown C. jejuni; identify structural genes required for anaerobic growth; compare the abilities of wild type and mutated strains to associate with human cells and colonise chickens; and identify genes involved in regulation of aerobic and anaerobic growth. We anticipate the identification of hitherto hidden virulence attributes associated with anaerobic growth.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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