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Intestinal colonisation factors common to E. coli O157 and other A/E lesion-forming lumenal microbial pathogens
Reference
D14378
Principal Investigator / Supervisor
Professor Gad Frankel
Co-Investigators /
Co-Supervisors
Dr Alan Phillips
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
186,136
Status
Completed
Type
Research Grant
Start date
01/02/2001
End date
01/02/2004
Duration
36 months
Abstract
The initial steps of enterohaemorrhagic E. coli (EHEC) infection involve intestinal colonisation and adaptation to the in vivo environment. Colonisation of human intestinal mucosa requires a functional LEE pathogenicity island encoding the adhesion molecule intimin. However, a large body of evidence points to the existence of additional colonisation factors. Here we propose to use STM of the mouse pathogen Citrobacter rodentium to discover new colonisation and survival factors. The function of the identified genes will be assessed in the EHEC background using the well-established technique of in vitro organ culture of intestinal mucosa. Results from this study should lead to the identification of new vaccine and anti-microbial targets.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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