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Diarrhoeal mechanisms of Campylobacter jejuni
Reference
D14376
Principal Investigator / Supervisor
Dr Paul Everest
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Veterinary School
Funding type
Research
Value (£)
176,320
Status
Completed
Type
Research Grant
Start date
18/06/2001
End date
18/06/2004
Duration
36 months
Abstract
We propose to study the signalling events in cells and tissues infected with Campylobacter jejuni to identify the molecular basis of fluid secretion initiated by this organism. From the very early stages of infection, bacterial components signal to cells to initiate inflammation and fluid loss from the gastrointestinal mucosa. These bacterial signals activate host molecules in the form of secondary messengers and protein kinases causing fluid secretion. We intend to concentrate on the role of bacterial cell surface molecules and identified bacterial toxins in these events. To this end (in collaboration) we have generated mutant campylobacters with defined alterations in these molecules.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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