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Award details
An investigation into the link between colonic function adipose tissue metabolism and insulin sensitivity
Reference
D14310
Principal Investigator / Supervisor
Professor Keith Frayn
Co-Investigators /
Co-Supervisors
Dr Derek Jewell
,
Dr M Robertson
Institution
University of Oxford
Department
Clinical Medicine
Funding type
Research
Value (£)
267,216
Status
Completed
Type
Research Grant
Start date
04/03/2001
End date
03/08/2004
Duration
41 months
Abstract
Insulin resistance underlies a collection of risk factors for developing type 2 diabetes and cardiovascular disease. Based upon observations made by the Recognised Researcher on this award and others, we propose that the colon plays an important part in normal maintenance of insulin sensitivity. We propose studies in which colonic fermentation will be modified acutely and over the longer-term (4 weeks), in which we will investigate changes to adipose tissue and skeletal muscle metabolism in vivo, and gene expression in these tissues. Observations in intact subjects will be compared with those lacking a colon. The results of these studies would form a firmer basis for dietary recommendations for avoidance of the insulin resistance syndrome.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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