Award details

The use of directed protein evolution in the generation of novel enzymes tailor-made for use in the animal feed industry

Reference	D14015
Principal Investigator / Supervisor	Professor Harry Gilbert
Co-Investigators / Co-Supervisors	Professor Gideon Davies
Institution	Newcastle University
Department	Agriculture Food and Rural Development
Funding type	Research
Value (£)	201,172
Status	Completed
Type	Research Grant
Start date	01/03/2001
End date	01/03/2004
Duration	36 months

Abstract

The inclusion of hemicellulases in poultry diets has numerous benefits for the livestock industry. The utility of current animal feed enzymes is limited by their susceptibility to environmental extremes. The recent technological developments in generating novel proteins could have a significant impact on the use of enzymes in animal feeds. The objective of this project is to test the hypothesis that modern protein evolutionary theory, and the identification of non-catalytic carbohydrate binding modules in a range of enzymes, can be applied to the livestock industry through the generation of novel biocatalysts tailor- made for the poultry industry. Xylanases will be used as the model proteins as they are widely used in the poultry industry, and the biophysical properties of these proteins are not optimal for use as feed enzymes.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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