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Chicken leptin: a candidate gene for body composition and reproductive performance
Reference
D13983
Principal Investigator / Supervisor
Professor Peter Sharp
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
The Roslin Institute Department
Funding type
Research
Value (£)
253,868
Status
Completed
Type
Research Grant
Start date
01/08/2001
End date
31/03/2005
Duration
44 months
Abstract
Leptin is a candidate gene for improved body composition and reproductive performance in domestic animals. The use of this gene for marker-assisted selection and QTL analysis in poultry has been hindered by failure to obtain genomic sequence of a chicken leptin homologue. We propose to clone the gene using an expression-based approach, taking advantage of the recent cloning of a chicken leptin receptor gene by a collaborator. Our aims are: 1) to screen a chicken adipose tissue cDNA expression library with both mammalian leptin nucleotide probes, and labelled recombinant chicken leptin receptor protein; 2) to obtain genomic sequence and map the gene to a chicken chromosome; and 3) to analyse the physiological regulation of leptin gene expression in broiler chickens.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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