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Award details
Local events in the tissues of animals infected with Salmonella
Reference
D13683
Principal Investigator / Supervisor
Dr Pietro Mastroeni
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Veterinary Medicine
Funding type
Research
Value (£)
221,524
Status
Completed
Type
Research Grant
Start date
08/01/2001
End date
07/07/2004
Duration
42 months
Abstract
We hypothesise that host resistance to primary sub-lethal Salmonella infections relies on local events that operate, at least in part, independently from systemic host responses. Thus, the aim of the project is to analyse the local events that occur in the tissues of animals infected with S. enterica serovar Typhimurium. Specifically we will investigate: 1) the identity and the state of activation of the phagocytic cells in infectious foci; 2) the site of bacterial localisation and the in situ activation or down-regulation of cytokine, chemokine, ROI, and RNI production; and 3) the evolution of individual infectious foci in relation to local or systemic events. The work will provide new fundamental knowledge on the pathogenesis of salmonellosis.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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