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The influence of bacteria and food antigens on T cell retention and clonal expansions in the gut mucosa

Reference	D13513
Principal Investigator / Supervisor	Professor Christopher Probert
Co-Investigators / Co-Supervisors	Dr Paul Bland
Institution	University of Bristol
Department	Physiology and Pharmacology
Funding type	Research
Value (£)	287,948
Status	Completed
Type	Research Grant
Start date	01/12/2000
End date	30/11/2003
Duration	36 months

Abstract

In the foetus there are few mucosal T cells, but during infancy they become more numerous and shift from a polyclonal to an oligoclonal receptor population. Integrins and addressins are responsible for T cell retention. The determinants of the skewing of the T cell population are unknown. At birth, the GI tract is sterile, but is quickly exposed to food and bacteria. We will investigate luminal factors determining T cell retention and clonal skewing. We will determine the phenotype, clonality and distribution of T cells and correlate this with the expression of integrins and addressins. The influence of food and luminal bacteria will be determined. In mice, the same group of observations will be made, but by manipulating their diet and microbial environment we will determine their relative impact in the developing gut immune system.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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