Award details

Molecular mechanisms involved in the dietary regulation of DMT1 expression in human intestinal epithelial cells

Reference	D13400
Principal Investigator / Supervisor	Professor Paul Sharp
Co-Investigators / Co-Supervisors	Professor Surjit Srai, Dr Mark Williams
Institution	University of Surrey
Department	Health and Medical Sciences
Funding type	Research
Value (£)	189,444
Status	Completed
Type	Research Grant
Start date	01/09/2000
End date	01/09/2003
Duration	36 months

Abstract

The nutritional significance of maintaining adequate dietary levels of the transition metals iron, zinc and copper is clear, due to their essential role in a plethora of biochemical events in the body. This is confirmed by the large number of pathologies associated with imbalances in metal ion homeostasis. There is good evidence, from studies on animals and cell lines, that dietary levels of individual metals can influence the absorption and utilisation of others. Our study, using the Caco- 2 TC7 cell model of human enterocytes, will investigate the biochemical basis for these dietary interactions and will focus on the putative metal ion transporter, DMT1. The data from this project will advance our knowledge of diet-gene interaction in regulating mineral metabolism at the cell and molecular level, and is thus relevant in understanding the underlying causes of metal ion deficiency and overload disorders.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search