Award details

Effect of dietary fatty acids on the intestinal mucosal barrier

Reference	D12873
Principal Investigator / Supervisor	Professor Christopher Hawkey
Co-Investigators / Co-Supervisors	Dr Andrew Bennett, Professor Yashwant Mahida
Institution	University of Nottingham
Department	Sch of Biomedical Sciences
Funding type	Research
Value (£)	209,120
Status	Completed
Type	Research Grant
Start date	01/06/2000
End date	01/06/2003
Duration	36 months

Abstract

This research arises from the observations suggesting that dietary polyunsaturated fatty acids (PUFA) affect gastrointestinal epithelial barrier function. We test the hypothesis that soluble products elaborated by subepithelial myofibroblasts are of key importance in this effect. We will investigate incorporation of PUFA into cell membranes and resulting changes in barrier function, chloride secretion, restitution and proliferation, and expression of molecules affecting tight junctions. We will use co-culture and conditioned media to distinguish direct effects on epithelial cells from those that are mediated from myofibroblasts. The research will enable a rational plan of testing strategies in humans to be developed subsequently.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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