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Dietary control of uncoupling protein 3 in human skeletal muscle: relevance to regulation of energy expenditure
Reference
D12783
Principal Investigator / Supervisor
Dr David White
Co-Investigators /
Co-Supervisors
Dr Andrew Bennett
,
Professor Ian Macdonald
Institution
University of Nottingham
Department
Sch of Biomedical Sciences
Funding type
Research
Value (£)
245,104
Status
Completed
Type
Research Grant
Start date
18/03/2000
End date
18/06/2003
Duration
39 months
Abstract
There is much evidence, particularly from animal models, for a role for mitochondrial uncoupling proteins (UCPs) in the energy expenditure component of energy homeostasis. UCP3 is of special interest since it is expressed mainly in skeletal muscle. This tissue constitutes the largest tissue mass in man, and is a major contributor to overall metabolic rate. We seek to determine the acute and chronic effects of diet on the expression of UCP3 in human skeletal muscle. Measurements of UCP3 mRNA and protein from biopsy samples taken after different dietary conditions will be related to changes in resting energy expenditure, substrate utilisation and thermogenic response.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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