Award details

An investigation of the effect of fish oil supplementation aspects of foam cell formation

Reference	D11873
Principal Investigator / Supervisor	Professor Parveen Yaqoob
Co-Investigators / Co-Supervisors	Professor David Leake
Institution	University of Reading
Department	Food and Nutritional Sciences
Funding type	Research
Value (£)	88,973
Status	Completed
Type	Research Grant
Start date	31/01/2000
End date	30/09/2001
Duration	20 months

Abstract

Recent work suggests that the transcription factor, PPARgamma, alters scavenger receptor expression in response to oxidised low-density lipoprotein (oxLDL) and therefore enhances foam cell formation, stimulating further uptake of oxLDL in a positive feedback loop. The proposed project is a preliminary study to explore the possibility that the effect of PPARgamma is subject to modulation by dietary manipulation of oxLDL. Human subjects will supplement their diet with fish oil and provide blood samples for the preparation of oxLDL and monocytes/macrophages. The effect of altered fatty acid composition of oxLDL on the expression of scavenger receptor CD36 through PPARgamma will be investigated.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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