Award details

The role of novel genes in the co-control of starvation-survival toxin production and stress resistance in Staphylococcus aureus

Reference	D11839
Principal Investigator / Supervisor	Professor Simon J. Foster
Co-Investigators / Co-Supervisors
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	154,180
Status	Completed
Type	Research Grant
Start date	10/01/2000
End date	10/01/2003
Duration	36 months

Abstract

The ability of bacterial food borne pathogens and spoilage organisms to withstand environmental assault in crucial to their survival in the food environment. S. aureus is a food poisoning organism and major human pathogen. A screen for starvation-survival mutants has identified novel genes, whose products link this response to the processes controlling toxic production, stress resistance and pathogenicity. Two of these genes encode a possible tellurite resistance determinant and an enzyme involved in nucleotide recycling, respectively. The project will give an in depth analysis of the mechanism of action and role of the novel components in multiple cellular functions. This will further our understanding of how S. aureus is able to adapt to changing environmental conditions in order to survive and potentially cause food poisoning.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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