BBSRC Portfolio Analyser
Award details
The regulation of IGF binding protein-2 mRNA expression in bovine granulosa cells: a key regulator of ovarian function
Reference
D11775
Principal Investigator / Supervisor
Dr David Armstrong
Co-Investigators /
Co-Supervisors
Institution
The Roslin Institute
Department
Dept of Reproductive & Env Physiology
Funding type
Research
Value (£)
166,948
Status
Completed
Type
Research Grant
Start date
01/08/2000
End date
01/08/2003
Duration
36 months
Abstract
The ovarian insulin-like growth factor (IGF) system regulates the response of granulosa and theca cells towards gonadotrophins. We have identified IGF binding protein-2 as a key component of this system by virtue of its ability to bind IGF and regulate its bioavailability. In cattle IGFBP-2 regulates the development of follicular dominance and mediates the effects of nutrition on the growth of small follicles. The aim of this project is to characterise the elements in the promoter involved in regulating the expression of mRNA encoding IGFBP-2. This new knowledge will increase our understanding of the regulation of follicle growth and will underpin the development of new technologies to increase yields of viable oocytes used for IVM and IVF.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search