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Molecular controls of meat quality: fibre-type specific regulation of porcine myosin heavy chain genes
Reference
D11603
Principal Investigator / Supervisor
Professor Kin-Chow Chang
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Veterinary School
Funding type
Research
Value (£)
147,620
Status
Completed
Type
Research Grant
Start date
01/01/2000
End date
01/01/2003
Duration
36 months
Abstract
The main objective is to generate basic farm animal information that leads to improvement of meat quality in pigs through modification of muscle fibre types. Individual muscles differ intrinsically in quality mainly because of differences in fibre type composition. Postnatal fibre typing is based on the expression of 4 major myosin heavy chain (MyHC) isoform genes (slow/1, 2a, 2x and 2b fibres). We recently cloned all 4 porcine MyHC promoters and that of the perinatal MyHC gene. We propose to identify critical DNA regulatory elements and novel porcine transcription factors associated with fibre-type specific MyHC expression, which include the use of direct DNA muscle transfers, subtractive hybridisations and transactivation assays.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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