BBSRC Portfolio Analyser
Award details
Preadaptation of Listeria monocytogenes for enhanced virulence involves CpG DNA methylation
Reference
D11599
Principal Investigator / Supervisor
Professor Catherine Rees
Co-Investigators /
Co-Supervisors
Dr Philip Hill
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
147,934
Status
Completed
Type
Research Grant
Start date
06/06/1999
End date
06/09/2002
Duration
39 months
Abstract
L. monocytogenes is an intracellular, pathogen that causes severe food-borne infections (listeriosis) following the ingestion of contaminated foods. It is unknown why serotypes (such as 4b and 1/2) are more likely to cause infection and are normally associated with large scale outbreaks of listeriosis. We have recently found that these pathogenic serotypes of this bacteria possess a CpG DNA methylation system which produces populations of cells with differing levels of methylation which correlate directly with virulence potential. This project aims to investigate the genetic mechanism controlling this phenomenon and its role in generating populations of bacteria with variable phenotypic traits.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search