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Award details
Role of secreted/outer proteins in immunity to Salmonella
Reference
D11572
Principal Investigator / Supervisor
Dr Anjam Khan
Co-Investigators /
Co-Supervisors
Professor John Robinson
Institution
Newcastle University
Department
School of Cell and Molecular Biosciences
Funding type
Research
Value (£)
267,136
Status
Completed
Type
Research Grant
Start date
01/01/2000
End date
01/11/2003
Duration
46 months
Abstract
This project focuses on the identification of extracellular/secreted proteins of Salmonella recognised by the immune response elicited by live vaccines, following our findings on responses to these proteins in mice. We will concentrate on identification of secreted proteins recognised by antibodies and T cells (especially CD4+) in protective CMI so as to pinpoint the antigens important in protection, and the possible role of CMI in determining the specificity of protection conferred by live vaccines. Cytotoxic responses are the subject of another BBSRC project. The long term aim shared by the two projects is to understand the mechanisms of immunity to Salmonella so as to enable the rational development of effective salmonella vaccines.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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