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Gut-brain signalling: roles of lipid cholecystokinin and the vagus nerve in man

Reference	D11518
Principal Investigator / Supervisor	Professor Graham Dockray
Co-Investigators / Co-Supervisors	Dr R Dimaline, Professor David Thompson, Professor Andrea Varro
Institution	University of Liverpool
Department	Physiology
Funding type	Research
Value (£)	299,289
Status	Completed
Type	Research Grant
Start date	01/10/1999
End date	01/10/2002
Duration	36 months

Abstract

The object of the proposed studies is to define how fat in the human intestine activates signals to the central nervous system that acutely regulate food intake, and that co-ordinate the processes of digestion. The proposal is based on our previous observations that in man, fatty acids with a chain length greater than C12 release the gut hormone cholecystokinin which in turn acts on CCK-A receptors on vagal afferent nerve fibres. The present proposals seek to (a) define the neurochemical basis of CCK actions on vagal afferent fibres in man, (b) elucidate the mechanisms that autoregulate CCK release in response to fatty acids, and (c) develop an electrophysiological approach to studying vagal afferent nerve discharge in response to intestinal fatty acid in man.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	X - not in an Initiative
Funding Scheme	X – not Funded via a specific Funding Scheme

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