BBSRC Portfolio Analyser
Award details
Molecular mechanisms by which dietary fatty acids modulate the function and differentiation of enterocytes
Reference
D11492
Principal Investigator / Supervisor
Dr J Higgins
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
237,464
Status
Completed
Type
Research Grant
Start date
01/08/1999
End date
01/08/2002
Duration
36 months
Abstract
Our previous studies have shown that feeding fat causes adaptation of the enterocytes of the small intestine to chylomicron assembly and secretion. Diets of different fatty acid composition have effects of different magnitude. The aim of the proposed study is to determine which dietary fatty acids are active in the modulation of enterocyte differentiation at a cellular level and over the villus/crypt gradient and to examine the mechanisms involved. The effect of dietary fatty acids on the regulation of chylomicron assembly at an intracellular biochemical level will be investigated and the effect on the expression of genes for key proteins will be determined.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search