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Award details
A spatial and temporal image system for cellular fluorescent probe microscopy
Reference
D11161
Principal Investigator / Supervisor
Professor Ian Connerton
Co-Investigators /
Co-Supervisors
Institution
University of Nottingham
Department
Sch of Biosciences
Funding type
Research
Value (£)
100,747
Status
Completed
Type
Research Grant
Start date
01/05/1999
End date
01/05/2002
Duration
36 months
Abstract
This study aims to develop a system for using calcium imaging techniques for the screening of cDNA libraries with the intention of cloning flavour receptors. All known vertebrate olfactory receptors and many gustatory receptors share a common seven transmembrane structure. Triggering of these receptors is often accompanied with the mobilisation of internal calcium stores, which may be visualised in individual cells loaded with fluorescent probes. Mammalian cell systems will be used to identify specific ligands for orphan flavour receptors identified through this project. This will be done by developing the software and equipment requested to establish a means of scanning and recording multiple fields of view during calcium imaging experiments.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
BioImaging (BI) [1998]
Funding Scheme
X – not Funded via a specific Funding Scheme
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