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Molecular insights into the role of dietary fibre and maintenance of colonic health
Reference
D11036
Principal Investigator / Supervisor
Professor Soraya Shirazi-Beechey
Co-Investigators /
Co-Supervisors
Institution
University of Liverpool
Department
Veterinary Preclinical Science
Funding type
Research
Value (£)
163,436
Status
Completed
Type
Research Grant
Start date
01/04/1999
End date
01/04/2002
Duration
36 months
Abstract
Dietary fibre and starch, which are not hydrolysed in the small intestine, are fermented in the lumen of the colon, by colonic microflora into short chain fatty acids (SCFA). SCFA, in particular butyrate, are pivotol in maintaining the homeostasis in colonic epithelial cells. We have identified the membrane protein and have shown that the expression of butyrate protein involved in the transport of butyrate across the luminal membrane and have shown that the expression of butyrate transported (BT) is regulated by the extracellular butyrate, primarily at the level of transcription. In the proposed program we aim to a) clone and characterise the BT gene promoter and b) identify butyrate-induced transcription factors which interact with regulatory elements within this promoter. This information is essential in elucidation of molecular and cellular events involved in the transcription of the BT gene in response to luminal butyrate.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
X - not in an Initiative
Funding Scheme
X – not Funded via a specific Funding Scheme
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